Applying the configuration is required each time a change is made to the TAC configuration in order for the change to take affect for the remote users.
To apply the configuration, click on Apply Configuration on the files menu or on the quick access bar.
Select Reset current session and enforce usage of the new configuration to implement the changes immediately. This will apply new configuration to the new sessions. Existing sessions will use the old configuration until they are logged out. Click Apply.
You can monitor the activation process. Any errors will be highlighted with supporting information. The initial activation might take time as it requires configuring Windows features and roles for the first time.